March 21, 2024 - IOBCF

IBA: Is This the Quiet Before a Radiopharmaceutical Storm?

Ion Beam Applications (IBA) recently released their full-year 2023 results, showcasing steady progress. However, a closer look at the earnings call transcript reveals a fascinating subplot: the rise of their "Other Accelerators" business. This segment, which includes radiopharmaceuticals and industrial applications of particle accelerators, has quietly become a significant growth driver, achieving a remarkable 51% revenue surge in 2023.

The excitement surrounding radiopharmaceuticals is intensifying, fueled by recent multi-billion dollar acquisitions of companies like RayzeBio and Point Biopharma. These deals highlight the immense potential of targeted radioligand therapy, a cutting-edge approach that delivers highly focused radiation directly to cancer cells, minimizing harm to surrounding healthy tissue.

IBA, with its deep expertise in radioisotope production accelerators, is perfectly positioned to capitalize on this expanding market. Their Cyclone KIUBE cyclotron, a compact workhorse for producing diagnostic and therapeutic isotopes, recently achieved a significant milestone - the sale of its 100th unit. This accomplishment signifies the widespread adoption of KIUBE as a cornerstone for radioisotope production, placing IBA at the core of a rapidly growing network of radiopharmaceutical facilities.

Further solidifying IBA's radiopharmaceutical ambitions is PanTera, their joint venture with the Belgian Nuclear Research Center (SCK CEN). This collaboration focuses on scaling up the production of Actinium-225, a highly sought-after radioisotope used in targeted therapies for various cancers.

"The recent supply agreement with TerraPower Isotopes and capacity reservation agreements with Bayer and another undisclosed customer clearly demonstrate PanTera's growing potential. These partnerships validate the demand for Actinium-225 and solidify IBA's role as a crucial supplier in the emerging Actinium-225 supply chain. As revealed during the earnings call, the planned construction of PanTera's large-scale production facility in 2025 further underscores the commitment to making this joint venture a radiopharmaceutical powerhouse."

Projected Growth of "Other Accelerators"

The following chart illustrates the projected revenue and REBIT growth of IBA's "Other Accelerators" segment, driven by the success of PanTera and the growing demand for radiopharmaceuticals.

The financial implications of this radiopharmaceutical strategy are significant. IBA's "Other Accelerators" segment, currently operating at an impressive 18% REBIT margin, could see its profitability skyrocket as PanTera reaches full operational capacity. The high-margin nature of radioisotope production, coupled with the escalating demand for therapeutic isotopes like Actinium-225, creates the potential for an earnings surge that could significantly outpace the growth of IBA's core proton therapy business.

While analysts remain focused on the recovery of proton therapy and IBA's long-term REBIT target of 10%, the real story may be unfolding behind the scenes. The rapid growth and strategic partnerships within the "Other Accelerators" segment suggest a potential radiopharmaceutical windfall that could propel IBA's profitability beyond current expectations.

"Key Supporting Data Points - 51% revenue growth in "Other Accelerators" in 2023 - Sale of the 100th Cyclone KIUBE cyclotron, indicating widespread adoption - Strategic partnerships with TerraPower Isotopes, Bayer, and an undisclosed customer for Actinium-225 production - Planned construction of PanTera's large-scale production facility in 2025 - Multi-billion dollar valuations of radiopharmaceutical companies acquired by large pharmaceutical companies"

As the global demand for targeted radioligand therapy explodes, IBA, with its strategic positioning and growing momentum, is poised to become a leading player in this exciting new frontier of cancer treatment.

"Fun Fact: IBA's roots can be traced back to a spin-off from the Catholic University of Louvain in 1986, driven by the vision of pioneering proton therapy technology for cancer treatment. From these humble beginnings, IBA has evolved into a global leader in medical technology, with a presence in over 40 countries."